Colescott made up an early deficit on her second leg, giving Cedeno the baton in the third position. The freshman was able to give Pfleegor the baton with the lead to start the anchor leg.
Williamsport sophomore Jaid Harsch made up the deficit quickly getting on Pfleegor's should on the back stretch.
"Yeah, up through there (Pfleegor pointed to the back stretch) I could hear her footsteps," Pfleegor said. "It just pushed me harder."
Selinsgrove thrower Courtney McCartney was one of three double winners in the Class AAA meet along with Harsch, who won both hurdles races and Danville's Shelby Freedman, who claimed the long jump and the javelin.
McCartney won the shot put with a throw of 44-10 ½ and the discus with a personal- and area-best throw of 126-6.
"I pretty much don't focus on nerves when it comes to meets like this," McCartney said. "My discus was really good. Hopefully, I set myself up well for states."
Freedman won the javelin with a throw of 130-10 and the long jump with a leap of 16-4 ¾.
Selinsgrove had three other champions on the day with Brianna Carnathan winning the 800, Alexis Auman winning the triple jump and Jessica Gill winning the pole vault.
Carnathan ran neck-and-neck for most of the two laps with Williamsport's Sarah Wirth, before outkicking the Millionaires' runner at the end to claim the title in 2:21.07
"I like to sit and kick, if I can wait on somebody's shoulder, I will. We were both hoping to hit the state qualifying time, but we didn't," Carnathan said. "She's a great person to race against and we're friends."
Auman's winning leap of 34-10 1/2, while Jessica Gill won the pole vault with a vault of 10-0.
Those championships were key as the Seals claimed the District 4 Class AAA title with 157 2/3 points with Williamsport finishing second.