Thursday's win was a far cry from earlier in the season when Lourdes won 41-40 at Schuylkill Haven.
Zavier Webb knocked down a 3-point basket 15 seconds into the game to give the Hurricanes a 3-0 lead. It was their only lead of the night.
Lourdes went on a 10-0 run to close a first quarter that saw Haven go scoreless for nearly 3 1/2 minutes.
Haven slowed the tempo in the second quarter, holding the ball without a shot for a 2-minute stretch at one point, as the teams combined for six points with Lourdes leading 19-11 at the break.
The third quarter belonged to Lourdes as an 11-0 run kept the winless Hurricanes off the board until there was 2:15 left in the quarter. The lead would balloon to 33-16 after three periods.
Czeponis made his presence felt down low as 10 of his came from the low post.
Lourdes recorded its first varsity win, 66-34 over Kulpmont, on Dec. 3, 1959.
Tom Ryan, now a broadcaster with Black Diamond Sports Network, was the first player through the doors on opening night.
"What I remember most about the first game was the crowd and the enthusiasm," Ryan said. "We had moved out from Shamokin Catholic where the gym was about 60-feet long and this (Lourdes) was the big court. It was a memorable occasion as a game to play in. The year we won the state title (1990) the team's only loss was to Schuylkill Haven."
That team went 20-8 on it way to the Class A state crown.
Matt Reiprish was the co-captain on that championship team and was at the game Thursday to witness history.
"One of the main things about the championship team was that were we pretty smart guys," he said. "All of us were in the Honor Society, and when we played we knew we could rely on one another.