Lourdes is coming off a 43-37 loss to Sullivan County on Tuesday while St. John Neumann defeated Muncy.
On the girls side in Class AAA, Danville faces a solid Athens squad for the championship.
The Lady Ironmen have been led all season by talented freshman Amber Renz and senior Siobhan Bross.
In Class AA, Maria Kelleher and Lewisburg take on Muncy on Friday at 6 in Milton for the consolation game with a state tournament berth at stake. While they play for the consolation, Mount Carmel, led by senior Christina Perles, faces Southern Columbia at 5 in Shamokin on Saturday for the District 4 Class AA title. The Red Tornadoes have won the past two straight District 4 Class AA championships and are looking to three-peat.
Lourdes plays for the Class A title against a talented Sayre squad on Saturday in Montoursville at 3. The Red Raiders are trying to continue their string of dominance by claiming a fifth consecutive District 4 title with a win on Saturday.
The top three teams in Class A and AA advance to the state tournament while only the top two finishers in Class AAA advance.