Keiser suffered a broken hand during Penn State's win over Kent State on Sept. 21, and has been out of game action ever since.
A vital piece to the Nittany Lions' special teams and a contributing safety, Keiser is officially listed as "possible" on Penn State's injury report. He will be further evaluated this week.
"Ryan Keiser is still questionable for the game," O'Brien announced. "We're hoping to have him, but we'll know more probably by the end of (today). We feel good about it, but I would say he's still questionable."
n Turnover differential
With a minus-three turnover differential, Penn State ranks among the bottom three teams in the Big Ten in that category. While they have surrendered five fumbles and four interceptions, the Nittany Lions have only created six turnovers (one fumble, five interceptions) through their first five games. O'Brien is looking for serious improvement.
"We definitely work on that; we really do," he said. "We do a lot of drills on that and coach it up. Whether it's ball drills, interception drills, strip drills, fumble recovery drills, blocked punt drills, we drill it. We need to do a better job in that area, no doubt about it. We' ve just got to keep working on it and emphasize it on film. When we see a good play -- somebody that caught an interception or recovered a fumble in practice -- say, 'Hey, great job,' and emphasize it. Hopefully we'll start getting that turned around a little bit."