Selinsgrove is under the guidance of Tom Garlock, who played his college lacrosse at Franklin & Marshall.
The Seals lost to Lewisburg 9-8 in the district finals last year after taking an early lead in the game.
"The players have to execute well on the field," Garlock said as to a key to winning the district this year.
The Seals have a young team but the offense and defense are well-balanced, according to Garlock.
"We hope to execute well and end the season with an improved record from last year (12-4)," he said. "We hope to build upon this and provide a foundation for upcoming seasons."
Garlock noted the loss in the district final, while disappointing, marked continuing improvement for the Seals program.
Mifflinburg is looking to rebound from a 1-12 season last year under head coach Susan Chlebowski. Chlebowski is the only boys coach not to have played the game.
"I helped to start the team as my son wanted to play," she said. "We got the program going in 2008. I played field hockey and this was a great opportunity as I wanted a positive outlet for my son."
Chlebowski said that she threw herself into it 100 percent and became a student of the game.
"It's getting a little easier after four years, but I am still reading, learning and watching videos to try and help this team get better. We lost some games that we should have won last year."
Two years ago, the team went 6-4.
"We have 17 players and that's a skeleton roster," she added. "We have a positive outlook. Our weakness is that we don't have a deep bench and at least five brand-new players out this year."